{"id":82,"date":"2025-08-09T08:39:21","date_gmt":"2025-08-08T23:39:21","guid":{"rendered":"https:\/\/jo-iin.com\/blog\/?p=82"},"modified":"2025-08-09T08:39:23","modified_gmt":"2025-08-08T23:39:23","slug":"post-82","status":"publish","type":"post","link":"https:\/\/jo-iin.com\/blog\/post-82\/","title":{"rendered":"100\u5e74\u3067\u3053\u3053\u307e\u3067\u9032\u5316\uff01\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u6b74\u53f2\u3092\u5c02\u9580\u533b\u304c\u89e3\u8aac\u3057\u307e\u3059"},"content":{"rendered":"\n<p>\u3053\u3093\u306b\u3061\u306f\u3002\u8c4a\u4e2d\u5e02\u3067\u7cd6\u5c3f\u75c5\u8a3a\u7642\u306b\u529b\u3092\u5165\u308c\u3066\u3044\u308b\u57ce\u533b\u9662\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u2e3b<\/p>\n\n\n\n<p>100\u5e74\u3067\u3053\u3053\u307e\u3067\u9032\u5316\uff01\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u3056\u3063\u304f\u308a\u5e74\u8868<\/p>\n\n\n\n<p>\u203b\u30b9\u30de\u30db\u3067\u8aad\u307f\u3084\u3059\u3044\u3088\u3046\u3001\u7d30\u304b\u306a\u85ac\u5264\u540d\u306f\u56f3\uff08\u4e0b\u306e\u753b\u50cf\uff09\u306b\u307e\u3068\u3081\u3066\u3044\u307e\u3059\u3002\u30bf\u30c3\u30d7\u3057\u3066\u62e1\u5927\u3057\u3066\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>\u2022 1920\u5e74\u4ee3 \u2015 \u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u767a\u898b<br>\u725b\u3084\u8c5a\u304b\u3089\u7cbe\u88fd\u3057\u305f\u300c\u52d5\u7269\u30a4\u30f3\u30b9\u30ea\u30f3\u300d\u304c\u547d\u3092\u6551\u3046\u6642\u4ee3\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u3002<br>\u2022 1950\u301c80\u5e74\u4ee3 \u2015 \u98f2\u307f\u85ac\uff08\u7d4c\u53e3\u85ac\uff09\u304c\u767b\u5834<br>\u2022 \u30b9\u30eb\u30db\u30cb\u30eb\u30a6\u30ec\u30a2\uff08SU\uff09\u85ac\u3067\u81b5\u81d3\u3092\u523a\u6fc0\u3057\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3002<br>\u2022 \u03b1-\u30b0\u30eb\u30b3\u30b7\u30c0\u30fc\u30bc\u963b\u5bb3\u85ac\u3067\u201c\u7cd6\u306e\u5438\u53ce\u30b9\u30d4\u30fc\u30c9\u201d\u3092\u3086\u3063\u304f\u308a\u306b\u3002<br>\u2022 \u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\uff08\u30e1\u30c8\u30db\u30eb\u30df\u30f3\uff09\u304c\u809d\u81d3\u306e\u7cd6\u653e\u51fa\u3092\u6291\u5236\u3002<br>\u2022 1990\u5e74\u4ee3 \u2015 \u201c\u30d2\u30c8\u578b\u201d\u30a4\u30f3\u30b9\u30ea\u30f3\u3078<br>\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u6280\u8853\u3067\u4e0d\u7d14\u7269\u304c\u6e1b\u308a\u3001\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u3082\u6539\u5584\u3002<br>\u2022 2000\u5e74\u4ee3 \u2015 \u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u6642\u4ee3\u306e\u5e55\u958b\u3051<br>\u2022 DPP-4 \u963b\u5bb3\u85ac\uff082009\u301c\uff09\u3067\u4f53\u5185\u30db\u30eb\u30e2\u30f3\u3008GLP-1\u3009\u306e\u50cd\u304d\u3092\u9577\u6301\u3061\u3002<br>\u2022 GLP-1 \u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff082010\u301c\uff09\u304c\u201c\u3084\u305b\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u201d\u3068\u547c\u3070\u308c\u8a71\u984c\u306b\u3002<br>\u2022 SGLT2 \u963b\u5bb3\u85ac\uff082014\u301c\uff09\u306f\u5c3f\u306b\u7cd6\u3092\u51fa\u3057\u3066\u3001\u5fc3\u81d3\u30fb\u814e\u81d3\u3082\u5b88\u308b\u85ac\u3068\u3057\u3066\u62e1\u5927\u3002<br>\u2022 2020\u5e74\u4ee3 \u2015 \u8907\u5408\uff06\u90311\u56de\u306e\u6642\u4ee3\u3078<br>\u2022 **GIP\/GLP-1 \u30c7\u30e5\u30a2\u30eb\u4f5c\u52d5\u85ac\uff08\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff1a\u30de\u30f3\u30b8\u30e3\u30ed\uff09**\u304c\u6e1b\u91cf\u52b9\u679c\u3067\u3082\u811a\u5149\u3002<br>\u2022 **\u9ad8\u5bb9\u91cfGLP-1\uff08\u30bb\u30de\u30b0\u30eb\u30c1\u30c92.4 mg\uff1a\u30a6\u30b4\u30fc\u30d3\uff09**\u306f\u80a5\u6e80\u6cbb\u7642\u85ac\u3068\u3057\u3066\u767b\u5834\u3002<br>\u2022 **\u90311\u56de\u306e\u8d85\u6301\u7d9a\u578b\u30a4\u30f3\u30b9\u30ea\u30f3\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u30a4\u30b3\u30c7\u30af\uff1a\u30a2\u30a6\u30a3\u30af\u30ea\uff09**\u304c\u65e5\u672c\u3067\u3082\u767a\u58f2\u3002 \ufffc<br>\u2022 \u56fa\u5b9a\u914d\u5408\u6ce8\u5c04\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\uff0bGLP-1\u3001DPP-4\uff0bSGLT2 \u306a\u3069\uff09\u3067\u6ce8\u5c04\u56de\u6570\u3068\u85ac\u5264\u6570\u3092\u6700\u5c0f\u9650\u306b\u3002<\/p>\n\n\n\n<p>\u2e3b<\/p>\n\n\n\n<p>\u6700\u8fd1\u306e\u30c8\u30ec\u30f3\u30c9\u3092\u4e00\u8a00\u3067<br>1. \u300c\u4f4e\u8840\u7cd6\u3092\u6e1b\u3089\u3057\u306a\u304c\u3089 HbA1c \u3092\u4e0b\u3052\u308b\u300d<br>\uff1d\u30a4\u30f3\u30b9\u30ea\u30f3\u3067\u306f\u306a\u304f\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u3084SGLT2\u3092\u8ce2\u304f\u7d44\u307f\u5408\u308f\u305b\u308b\u6642\u4ee3\u3002<br>2. \u300c\u5fc3\u81d3\u30fb\u814e\u81d3\u3082\u5b88\u308b\u300d<br>SGLT2\u963b\u5bb3\u85ac\u3084GLP-1\u4f5c\u52d5\u85ac\u306b\u306f\u3001\u8840\u7cd6\u5024\u3092\u8d85\u3048\u305f\u201c\uff0b\u03b1\u52b9\u679c\u201d\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br>3. \u300c\u6ce8\u5c04\u306f\u90311\u56de\u30fb\u30da\u30f31\u672c\u300d<br>\u304b\u3064\u3066\u6bce\u65e54\u56de\u3060\u3063\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u6ce8\u5c04\u304c\u3001\u90311\u56de\u306e\u30a2\u30a6\u30a3\u30af\u30ea\u3067\u6e08\u3080\u60a3\u8005\u3055\u3093\u3082\u3002 \ufffc<\/p>\n\n\n\n<p>\u2e3b<\/p>\n\n\n\n<p>\u5f53\u9662\u304b\u3089\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<br>\u2022 \u6cbb\u7642\u6cd5\u306f\u300c\u6b74\u53f2\uff1d\u5b89\u5168\u6027\u300d\u3068\u300c\u6700\u65b0\uff1d\u5229\u4fbf\u6027\u300d\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5927\u5207\u3067\u3059\u3002<br>\u2022 \u76ee\u6a19\u5024\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306b\u5408\u308f\u305b\u3066\u85ac\u3092\u7d44\u307f\u5408\u308f\u305b\u308c\u3070\u3001<br>\u201c\u6016\u3044\u4f4e\u8840\u7cd6\u304c\u307b\u3068\u3093\u3069\u306a\u3044\u6cbb\u7642\u201d \u3082\u4eca\u3084\u73fe\u5b9f\u7684\u3067\u3059\u3002<br>\u2022 \u65b0\u85ac\u306b\u306f\u300c\u8cbb\u7528\u300d\u300c\u6ce8\u5c04\u306e\u6163\u308c\u300d\u300c\u81ea\u5df1\u7ba1\u7406\u300d\u304c\u4f34\u3044\u307e\u3059\u3002<br>\u6c17\u306b\u306a\u308b\u85ac\u304c\u3042\u308c\u3070\u3001\u53d7\u8a3a\u6642\u306b\u9060\u616e\u306a\u304f\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>\u2e3b<\/p>\n\n\n\n<p>\u307e\u3068\u3081<\/p>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306f\u3053\u306e100\u5e74\u3067\u201c\u547d\u3092\u3064\u306a\u3050\u6cbb\u7642\u201d\u304b\u3089\u201c\u751f\u6d3b\u306e\u8cea\u3092\u4e0a\u3052\u308b\u6cbb\u7642\u201d\u3078\u5927\u9032\u5316\u3057\u307e\u3057\u305f\u3002<br>\u6bce\u65e5\u306e\u8840\u7cd6\u6e2c\u5b9a\u3084\u6ce8\u5c04\u304c\u5927\u304d\u306a\u8ca0\u62c5\u3060\u3063\u305f\u6642\u4ee3\u3068\u6bd4\u3079\u3001\u4eca\u306f\u90311\u56de\u306e\u6ce8\u5c04\u30841\u65e51\u56de\u306e\u98f2\u307f\u85ac\u3067\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u9078\u629e\u80a2\u3082\u3042\u308a\u307e\u3059\u3002\u57ce\u533b\u9662\u3067\u306f\u3001\u3042\u306a\u305f\u306e\u751f\u6d3b\u306b\u30d5\u30a3\u30c3\u30c8\u3059\u308b\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u6cbb\u7642\u3092\u63d0\u6848\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u2e3b<\/p>\n\n\n\n<p>\u25bc\u56f3\uff1a\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac100\u5e74\u306e\u6b74\u53f2\uff08\u5f53\u9662\u4f5c\u6210\uff09<br>\uff0a\u30b9\u30de\u30db\u306e\u65b9\u306f\u753b\u50cf\u3092\u30d4\u30f3\u30c1\u30a2\u30a6\u30c8\u3057\u3066\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<figure 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